P2RY1 and epilepsy: Interestingly, purinergic P2Y1 receptors located on astrocytes are overexpressed in the epilepsy [12,34,35], and recently, we have shown that its blocked diminished slow Ca2+ transient in astrocyte [6] opens the possibility that the increase in astroglia Ca2+ transients in PTZ-kindling model could be due in part to an increase in P2Y1 receptors function.