To understand the positive dynamics of indicators of hepatic steatosis and fibrosis, the fact that hypoxia conditioning is thought to benefit smooth muscles in blood vessels but also elsewhere, including the bladder and gastrointestinal tract, mediated by diverse pathways involving heme oxygenase-1, NO, HIFs, VEGF, ATP-sensitive K+ channels, prostaglandins, bradykinin, different protein kinases, and ROS [55], normalizing the drainage and detoxification functions of the liver [56] and the barrier properties of the intestinal wall. The gene discussed is HMOX1; the disease is fatty liver disease.