In the choline metabolism in cancer (ko05231) pathway, SLC22A1 and SLC44A1, located in the cell membrane transporter, were significantly upregulated in the cold season, which could significantly improve the efficiency of the transporter’s transmembrane transport of the metabolite choline and transport more choline into the cell to participate in the glycerophospholipid metabolism cycle. The gene discussed is SLC44A1; the disease is cancer.