Among the 24 miRNA targeted genes downregulated in the cold season, 1453 differential targeted genes were significantly enriched in 26 signaling pathways, which were mainly enriched in axon guidance (ko04360), insulin resistance (ko04931), basal cell carcinoma (ko05217), tight junction (ko04530), glycerophospholipid metabolism (ko00564), microRNAs in cancer (ko05206), and phosphatidylinositol signaling system (ko04070) in the pathways (Figure 4B). The gene discussed is INS; the disease is cancer.