PTEN and Hepatic fibrosis: On the contrary, a blockade of the PPARα signaling pathway may result in lipid accumulation in the liver [99]; miR-129-5p downregulates the paternally expressed gene 3 (PEG3)-induced activation of hematopoietic stem cells [114], and miR-188-5p inhibition inhibits the activation of HSCs via the PTEN/PI3K/Akt pathway, alleviating liver fibrosis [115] (Table 2).