CCL4 and Hepatic fibrosis: The exosomes that are secreted by mesenchymal stem cells derived from adipose tissue typically express high levels of miR-122, which is known to have an inhibitory effect on liver fibrosis in in vivo systems; the administration of miR-122 to mice with CCL4-induced liver injury via hematopoietic stem cells was found to inhibit liver fibrosis by suppressing the activation of these exosomes [132].