In addition, immunostainings performed on skin biopsies of patients with morphea, a form of localized scleroderma, suggested the involvement of EMT based on the upregulation of mesenchymal markers such as TGF-β1, α-SMA, fibronectin and SNAI1 and the downregulation of E-cadherin [232]. Here, ACTA1 is linked to localized scleroderma.