Lymphatic endothelial cells were also linked with endoMT during histological analyses of skin sections from patients with SSc hybrid cells coexpressing lymphatic vessel endothelial hyaluronan receptor-1 LYVE-1, a specific marker of lymphatic endothelial cells, and α-SMA was found exclusively in the fibrotic skin of SSc patients. This evidence concerns the gene ACTA1 and systemic sclerosis.