TP53 and acute myeloid leukemia: In this sense, it has been suggested that SIRT1 could be key in the induction of chemoresistance in leukemia via the deregulation of p53 in AML and p53, Ku70, FoxO1, and Hsp90 in CML, nonhistone substrates deacetylated and inactivated by SIRT1 [7,8].