SIRT1, in addition to participating in healthy hematopoiesis and in the maintenance of hematological malignancies such as acute myeloid leukemia (AML), chronic myelogenous leukemia (CML), mixed phenotype acute leukemia (MPAL), T-cell acute lymphoblastic leukemia (T-ALL), chronic lymphocytic leukemia (CLL), and diffuse large B-cell lymphoma (DLBCL), is increased [3,4,52]. This evidence concerns the gene SIRT1 and B-cell chronic lymphocytic leukemia.