When the mRNA and protein expression levels of Sirt1 and PGC-1a were compared in the cytarabine-resistant Kasumi-1 cell line and its parental cells, higher Sirt1 and PGC-1a expression was found in the cytarabine-resistant cell lines; thus, the authors suggest that high coexpression of Sirt1 and PGC-1a may mediate drug resistance in these AML cells [5]. The gene discussed is SIRT1; the disease is acute myeloid leukemia.