The levels of the gene and protein expression of PPARγ, AMPK, and insulin-degrading enzyme (IDE) significantly decrease after the STZ induction of T2D in mice with an AD model (APPSwe/PS1), while in transgenic APPSwe/PS1 mice, as well as in wild-type mice with an STZ T2D model, there were no significant differences from control animals. Here, IDE is linked to Alzheimer disease.