Amyloid formation in the islets of Langerhans is one of the main causes of the death of hormone-producing pancreatic cells in both type 1 diabetes and T2D, when insulin resistance leads to a compensatory increase in insulin and IAPP production, which, in turn, leads to an increase in amyloidosis in the islets of Langerhans and their involution. This evidence concerns the gene IAPP and Insulin resistance.