Specifically, these analyses found pathway enrichment for IFN signaling (both type I and interferon-gamma), transcription by NF-kB and autoimmune diseases where secondary SjD or overlap is common (systemic sclerosis, SLE, rheumatoid arthritis and primary biliary cholangitis/primary biliary cirrhosis). Here, NFKB1 is linked to systemic lupus erythematosus.