RNA sequencing and genome-wide genotyping of monocyte-derived macrophages was performed in SSc patients and revealed an upregulation in the expression levels of genes involved in various metabolic pathways, including glycolysis, hypoxia, and mTOR signaling [44], further suggesting that trained immunity-like processes may play a role in the persistent deregulation of immune responses in SSc. Here, MTOR is linked to systemic sclerosis.