Results showed that LPSF/GQ-16 not only influenced the PBMCs’ production of IL-2, IL-4, IL-6, IL-17A, TNF, and IFN-γ, but also reduced skin thickening, downregulated biomarkers of skin and lung fibrosis, as well as decreased the activation of immune cells in the experimental model [8]. Here, IL4 is linked to pulmonary fibrosis.