Interestingly, serum CRP levels were significantly higher in MPA patients who have progressed to ESRD and those without ESRD compared to the control group (p < 0.0001), but there was no significance in serum CRP levels between MPA patients who have progressed to ESRD and those without ESRD (p = 0.22). The gene discussed is CRP; the disease is microscopic polyangiitis.