Moreover, the anti-apoptotic effect induced by downregulation of TRADD, FADD in peripheral blood mononuclear cells (PBMCs) from patients with SLE has been demonstrated, while the TNFR1–TRADD–FADD system may lead to apoptotic signaling [26]. The gene discussed is TNFRSF1A; the disease is systemic lupus erythematosus.