Nevertheless, the unique EEG spectral signature of hippocampal soluble Aβo obtained here using electrodes at the surface of the cerebral cortex shows a translational potential as a biomarker of preclinical and/or prodromal stages of AD, when soluble Aβo begin to accumulate before amyloid plaque deposition, tau pathology, brain structure alterations, and cognitive deficits emerge. This evidence concerns the gene ABO and Cognitive impairment.