We found that hemodialysis duration 8 ~ 15 years, hemodialysis duration 16 ~ 21 years, having hypotension during last hemodialysis, having hyperglycemia on the latest hemodialysis night, disturbance of potassium metabolism and serum albumin < 35 g/L were predictors of hypoglycemia during hemodialysis for the patients with DN (Table 3). The gene discussed is ALB; the disease is Hypoglycemia.