Through our investigation, we have identified key molecular targets, including STAT3, MAPK14, MAPK8, CASP3, and others, which are regulated by Danshenol C. This regulation leads to the activation of specific signaling pathways, such as MAPK, JAK-STAT signaling, and TNF signaling pathways, critical in the context of PF treatment. The gene discussed is MAPK8; the disease is pemphigus foliaceus.