Moreover, among those retrieved, the sole study by Colomb et al. [59] investigated the effect of TIGR/MYOC gene on POAG phenotype on 142 patients, demonstrating that the G allele (MYOC.mt1) is associated with increased impairment of visual field (P = 0.02), IOP (+ 4.9 mmHg, P = 0.0004) and slower decrease of IOP after therapy with primarily topical beta-blockers that could be associated with miotics. This evidence concerns the gene MYOC and open-angle glaucoma.