The study of Cui et al. [60] assessed the association of the following SNPs with the pharmacological response to POAG: rs11723068 G > A and rs757253 T > C of the Actin filament-associated protein (AFAP) gene; rs9503012 C > T and rs17134549 T > A of the GDP-mannose 4,6 dehydratase (GMDS) gene; rs3753380 C > T and rs3766355 A > C of the prostaglandin F2 receptor negative regulator (PTGFR). The gene discussed is PTGFRN; the disease is open-angle glaucoma.