Query of the phenoscanner database [58], however, revealed several adiposity and diabetes-related traits for the trans-SNP rs2012444, which seems plausible given the correlation of FABP-4 with body fatness measures and the previously observed association with type 2 diabetes [6], but suggests that this trans-SNP is associated besides FABP-4 with two established CRC risk factors, i.e., could be an invalid instrumental variable due to pleiotropic effects. This evidence concerns the gene FABP4 and diabetes mellitus.