AFP and hepatocellular carcinoma: In this study, well-known HCC death-related risk factors such as portal vein tumor thrombus (PVTT, log-rank P < 0.0001, HR = 3.363, 95%CI = 2.494–4.535, Supplementary Table S1), α-fetoprotein (AFP, log-rank P = 0.041, HR = 1.334, 95%CI = 1.009–1.765, Supplementary Table S1), and Barcelona Clinic Liver Cancer (BCLC, log-rank P < 0.0001, B stage vs. A stage: HR = 1.769, 95%CI = 1.221–2.561; C stage vs. A stage: HR = 3.355, 95%CI = 2.486–4.527, Supplementary Table S1) stage were all observed to be markedly related to HBV-related HCC prognosis in this study.