Jiang et al. also used the GWAS method to find that SNPs on STAT4 and HLA-DQ genes may be significantly correlated with HBV-related HCC susceptibility through large sample and multi-center methods, and they also found that the allele of the SNP locus of STAT4 was significantly correlated with its mRNA expression level [28]. This evidence concerns the gene STAT4 and hepatocellular carcinoma.