ORC1 and adrenal cortex carcinoma: ORC1 was highly expressed in different types of tumors tissues and matched normal tissues, as detected from the Cancer Genome Atlas (TCGA) and validated by datasets from the gene expression omnibus (GEO) database [29].To explore the relationship between ORC1 expression and clinicopathological features, analysis of the GEPIA2 and UALCAN databases revealed a significant difference in ORC1 expression levels with increasing pathology in ACC, LUAD, OV and SKCM.