In fact, hyperglycemia can facilitate the accumulation of ROS through different metabolic pathways: (1) enhanced polyol activity, causing sorbitol and fructose accumulation; (2) increased formation of advanced glycation end products (AGEs); (3) activation of protein kinase C (PKC) [33] and (4) increased hexosamine pathway flux [34]. Here, PRRT2 is linked to Hyperglycemia.