For the diagnosis of APS, classification criteria were developed that include, along with clinical manifestations (thromboses and obstetric pathology), the detection of antibodies to PLs (aPLs), including IgG/IgM antibodies to cardiolipin (aCL), IgG/IgM antibodies to β2-glycoprotein 1 (anti-β2-GP1), and lupus anticoagulant (LA) [5, 6]. Here, CD40LG is linked to autoimmune polyendocrinopathy.