Given the findings herein presented showing that YTHDC1 plays a protective role in COAD, BRCA, KIRP and KIRC, YTHDC2 promotes PFS in KIRC, CHOL and READ, while YTHDF3 could be a potentially protective factor in KIRC and LUSC, the certain protein of YTH domain family would be developed as a new prognosis biomarker or treatment target for cancer. The gene discussed is YTHDC2; the disease is cancer.