CDK4 and neoplasm: We found that Cdk4−/− tumor could grow at a similar rate as vector cells and Cdk6−/− tumor could grow to bigger size in Ifnar1−/− mice than those in WT C57 mice, suggesting the important role of IFNAR-1 in TME for the anti-tumor immunity activated in Cdk4−/− and Cdk6−/− cancer cells (Figs. 3h and 5j).