There was no significant difference between Cdk6−/−/Mavs−/− and Cdk6−/− tumor growth, while Cdk6−/−/Sting−/− tumors grew larger than Cdk6−/− tumors (Fig. 6e), suggesting that STING pathway was involved in Cdk6 deficiency mediated anti-tumor effect. Here, CDK6 is linked to neoplasm.