Compared with Normal and FCC groups, TPL2 expression levels were significantly increased in DCIS and IDC groups (Fig. 1a, b, DCIS vs Normal: P = 0.002; IDC vs Normal: P = 0.007; DCIS vs FCC: P = 0.008; IDC vs FCC: P = 0.04), but there were no significant differences between the FCC group and the Normal group, and also between the DCIS group and the IDC group (Fig. 1b, FCC vs Normal: P = 0.598; DCIS vs IDC: P = 0.242). The gene discussed is MAP3K8; the disease is ductal breast carcinoma in situ.