In addition, the authors demonstrated that interleukin-22 promotes epithelial cell transformation and breast cancer development by increasing TPL2 phosphorylation and subsequently activating MEK–ERK, JNK–c-Jun, and STAT3 signaling pathways, and Pin1 was identified as a major positive regulator of these signaling pathways14. The gene discussed is MAP2K7; the disease is breast carcinoma.