As shown in Fig. 7a, b and Supplementary Fig. S8a, b, again, HHT effectively activated JNK, leading to upregulated expression of nucleolar USP36 and Snail1, accompanied by little apoptosis in triple-negative breast cancer SUM159, HCC1806, or Hs 578T cells. Here, MAPK8 is linked to triple-negative breast carcinoma.