HARS1 and schizophrenia: Four SZ-based PRSs were estimated: one summarizing the global schizophrenia polygenic burden (Global PRSSZ), another specific to HARs (HARs PRSSZ), as well as two PRSs specific to HARs linked to transcriptional regulatory elements active in the foetal (FB-HARs PRSSZ) and adult brain (AB-HARs PRSSZ).