The frequency of the minor allele rs6691117G was significantly lower in dengue patients and in those with severe dengue compared to those in the healthy controls (OR = 0.73, 95% CI 0.54–0.99, P = 0.045; OR = 0.21, 95% CI 0.07–0.63, P = 0.005) suggesting that the CR1 SNP rs6691117A/G are associated with protection from dengue fever. This evidence concerns the gene CR1 and dengue disease.