Regarding CR1 polymorphisms, studies have shown the association of CR1 gene polymorphisms with various diseases such as Alzheimer's disease, systemic lupus erythematosus (SLE), lower erythrocyte sedimentation rate, spontaneous idiopathic preterm birth, cancer, and infectious diseases17,28–32. The gene discussed is CR1; the disease is early-onset autosomal dominant Alzheimer disease.