CR2 and dengue disease: In the CR2 gene, the frequency of minor allele rs1048971A was found to be significantly higher in patients with severe dengue compared to those in patients with dengue fever (OR = 2.2, 95% CI 0.9–5.4, P = 0.048) and those in patients with DWS (OR = 2.3, 95% CI 0.9–5.8, P = 0.045) suggesting that the CR2 SNP rs1048971G/A are associated with an increased risk of progressing to severe dengue (Supplementary table 4).