Treatment with LPS for longer time (24 h) induced the expression of inflammatory genes Il-1a, Nlrp3, interferon-induced genes Gbp3, Cd69, Oasl1, immune activation genes H2-M2, Ddx58, Socs3, Vnn3, Igtp, and the mitochondrially-localized Sod2, and decreased the expression of microglial markers Pla2g15, Cx3cr1, Cd300lb, and of genes related to Alzheimer’s Disease, such as Pald1, Igf1, Plau, Flt1, and the immune cell differentiation gene Cebpa (Fig. 1D, Supplementary Dataset 2) when compared to the control cells. Here, RIGI is linked to early-onset autosomal dominant Alzheimer disease.