Since we also noticed that the expression of ATF3 gradually decreased along the pseudotime PCC trajectory, this led us to speculate that the expression level of ATF3 could also play an essential role in cell-cycle regulation, and compounds upregulating ATF3 expression, such as sangivamycin, could prevent repopulation of quiescent cancer cells, encouraging us to study the possibility of using sangivamycin between chemotherapy cycles to delay tumor recurrence. Here, ATF3 is linked to cancer.