DDIT4 and neoplasm: We also noted co-upregulation of TRIB3, DDIT4 and ATF3 expression levels between normal and tumor samples from TCGA COAD RNA-Seq data (Fig. 6C) and interrelated expression levels of TRIB3, DDIT4 and ATF3 in different cell types of colon tissue (Supplementary Fig. S6B, C), suggesting that DDIT4, TRIB3 and ATF3/4 could simultaneously increase in cells treated with sangivamycin.