CDH5 and atherosclerosis: To investigate the biological significance of our findings, we generated the inducible EC-specific Ddr1 knockout mice Ddr1iECKO (Ddr1flox/flox, Cdh5-CreERT2+) (Supplementary Fig. 2A, B) and employed the mice to test the role of endothelial DDR1 in disturbed flow-accelerated vascular inflammation and atherosclerosis.