Among those are THBS1, encoding thrombospondin-1, involved in the assembly of neural circuits44; KCNN4, encoding the potassium channel KCa3.1, relevant for autonomous rhythmic activity in glioma networks45; and several other genes crucial for the formation of tumour microtubes of high importance for receiving neurogliomal synaptic input46,47. The gene discussed is THBS1; the disease is central nervous system cancer.