An experimental study has also shown a link between LAG3 Tregs and type I IFN signaling by demonstrating that blocking the receptor for type I IFNs (IFNAR1) by an antibody to IFNAR1 significantly reduced the proliferation of LAG3 Tregs and their immunosuppression effect in mice injected with myeloma cells11. The gene discussed is IFNAR1; the disease is plasma cell myeloma.