However, we noticed that in severe COVID-19 patients with auto-Abs to type I IFNs, cTregs/uTregs had lower level of LAG3+ suppressive effector molecule compared to their counterparts (22% decrease in the frequency of LAG3+ cTregs/uTregs, P = 0.03; Fig. 1H,I), which may suggest a lower immunoregulatory capability of cTregs/uTregs from auto-Abs IFNs positive patients. The gene discussed is LAG3; the disease is COVID-19.