Changes in some candidate genes including Chloride voltage-gated channel 5 (CLCN5), Calcium sensing receptor (CASR), CoA-disulfide reductase (CDR), Transient receptor potential cation channel subfamily V member 5 (TRPV5) and Adenylate cyclase 10 (ADCY10) have been described to be involved in the pathogenesis of idiopathic hypercalciuria and closely correlated with nephrolithiasis [8]. The gene discussed is CASR; the disease is nephrolithiasis.