Next, the coimmunoprecipitation-western blot results showed that firstly Sorcin interacted with NLRP3 inflammasome proteins (NLRP3 and Caspase-1) in 293T cells, further verifying an endogenous interaction between Caspase-1 and Sorcin in HuH7 and HCC-LM3 cells (Fig. 4B–F). This evidence concerns the gene SRI and hepatocellular carcinoma.