Western blot results further revealed that by blocking NLRP3 with MCC950, Sorcin inhibition-induced upregulation of Caspase-1, GSDMD, IL-1β, and IL-18 proteins was notably inhibited in HCC-LM3 and HuH7 cells (Fig. 5A, B). This evidence concerns the gene CASP1 and hepatocellular carcinoma.