Additionally, Sorcin could regulate the apoptosis pathway to promote tumor progression, and overexpression of Sorcin leads to a significant decrease in cytosolic calcium levels and enhanced cell apoptosis resistance, which could prevent endoplasmic reticulum stress and escape apoptosis caused by chemotherapy drugs [17] while silencing Sorcin leads to increased levels of pro-apoptotic genes and induction of mitochondrial apoptotic pathways in cancer [18]. The gene discussed is SRI; the disease is cancer.