Western blot results revealed that Sorcin-silenced increased the upregulation of pyroptosis-related proteins, while knockdown Caspase-1 reduced the upregulation of GSDMD-N, IL-1β, and IL-18 caused by Sorcin silencing in HCC cells (Fig. 6A, B). This evidence concerns the gene CASP1 and hepatocellular carcinoma.