In our study, Sorcin negatively regulates NLRP3 inflammasome in HCC cells, likely because of the interaction of highly expressed Sorcin with NLRP3 inflammasome, interfering with the activation and assembly of NLRP3 inflammasome, which are essential for host defense against pathogen invasion and maintenance of homeostasis, and thus decreasing host defense against pathogen invasion, resulting in weakened immune protection of the host. The gene discussed is NLRP3; the disease is hepatocellular carcinoma.