Along this line, Vanin1 pantetheinase that regulates the generation of the coenzyme A (CoA) precursor pantothenate (Pan), also known as vitamin B5 (VitB5) (Naquet et al, 2020; Millet et al, 2022), acts as a negative regulator of spontaneous sarcoma development in a p16/p19-deficient tumor-prone mouse model (Giessner et al, 2018). This evidence concerns the gene VNN1 and sarcoma.