BNIP3 and neoplasm: Volcano plot analysis of the myeloid metacluster showed that control tumors were enriched in Arg1 and Bnip3, Pgam1, Ldha, Ddit4 transcripts (Figs 3E and S7B for D20 and D28 tumors, respectively) associated with M2 polarization and tumor hypoxia (Semenza, 2013).