MAPT and Alzheimer disease: Post-traumatic neurodegeneration is likely to be dynamic over time and a specific temporal pattern of plasma p-tau isoform changes, as seen in AD where plasma p-tau231 precedes p-tau181 positivity, with both markers well correlated with τ PET.4 Very long-term follow-up incorporating comprehensive longitudinal fluid biomarker assessment, brain volumetry and molecular imaging would likely be highly informative.