In mice, intracerebral injections of pathologic tau show cell-type specificity similar to that of the human disease from which the tau was sourced (43, 58, 61, 65, 66).Injecting tau seeds from AD, CBD, PiD, and PSP into mice showed cell-type specificity and tau isoform specificity that matched that of the original disease even through repetitive in vivo seeding procedures (58). This evidence concerns the gene MAPT and Alzheimer disease.