Additionally, PiD seeds composed of only 3R tau could not induce pathology in 4R-only mice, PSP/CBD seeds composed of only 4R tau could not induce pathology in 3R-only mice, and AD seeds composed of 3R+4R tau could induce tau in both 3R-only and 4R-only mice (58). This evidence concerns the gene MAPT and pelvic inflammatory disease.