Our results suggest an evolving role for EMT-TFs during the progression from benign ductal epithelium through non-invasive neoplasia (abnormal cells in which the process of EMT may have started but which have not yet lost E-cadherin expression and thus retain the epithelial property of cohesion) to malignancy (in which the process of EMT is almost or fully complete). Here, CDH1 is linked to neoplasm.