The regulation of the balance depends on the cell type and context, however, there is still no sufficient data on the molecular coordinator of the ratio of linear and circular isoforms, and it is not known whether inhibition of linear ANRIL isoforms is sufficient to protect against CHD and DM2.[30] Perhaps this special influence of ANRIL can also explain the paradox when the genes involved in the biology of traits show different effects. Here, CDKN2B-AS1 is linked to coronary artery disorder.