The propensity for plaque rupture was explained by the low number of smooth muscle cells due to the high expression of CDKN2B-AS1, which revealed the need to use rs1333049 as a genetic marker to isolate a group of patients with DM2 for careful cardiac monitoring.[37] It was previously determined that CHD and myocardial infarction belong to different risk haplotypes at the chromosomal locus 9p21.3.[24] Hence, transcriptional dysregulation as one of the causes for the onset of at least 15% of cases of T2D and ischemic heart disease (IHD) appears compelling. This evidence concerns the gene CDKN2B and type 2 diabetes mellitus.