CDKN2B-AS1 and coronary artery disorder: Thus, the assumptions about the shared starting point of DM2 and CHD development as a result of a transcriptional error at the 9p21.3 chromosomal locus influenced by ANRIL are quite convincing and continue to be supplemented through scientific research.[54] DM2 and CHD represent a complex phenotype determined by genetic factors and environmental factors.