In this case, the phenotype of the target tissue cell acquires prognostic significance in the development of СHD and DM2.[35] The study group of Indumathi B et al, seeking to identify epigenetic signatures characteristic of CHD, concluded that hypomethylation of the locus causes activation of CDKN2A increasing the risk of CHD by 1.79 times, which is on par with similar epigenetic traits that were noted in the early onset of DM2.[36]. Here, CDKN2A is linked to Huntington disease.