The first scientific data on the p15/CDKN2B-p16/CDKN2A-p14/gene encoding protein ADP ribosylation factor locus gene cluster were associated with the largest family of 7 syndromes of the melanoma-neural system and detection using heterozygosity mapping based on microsatellite markers of the 9p21 large germline deletion. This evidence concerns the gene CDKN2A and melanoma.