CDKN2B and coronary artery disorder: Specifically, the CDKN2B-AS gene, through ANRIL, influences the cellular growth and proliferation of pancreatic beta cells and smooth muscle cells of the vascular wall, forming the future phenotype of “DM2 and CHD.”[47] The locus induced and controlled by ANRIL also contributes to the involvement of various factors at multiple levels of the system, contributing to the diversity of disease endophenotypes unrelated to the 9p21.3 chromosomal locus.