Previous studies have shown that Quercetin regulates apoptosis in breast cancer cells by regulating Bcl2/BAX inhibition of the PI3K/Akt pathway.[44] Luteolin inhibits VEGF-induced angiogenesis, thereby preventing progestin-driven breast cancer growth and progression.[45] Wedelolactone suppresses the activity of breast cancer cells by acting as inhibitors of multiple proteases.[46] The studies further suggest that the components might be the main active components of Ecliptae Herba in breast cancer treatment. This evidence concerns the gene VEGFA and breast cancer.