However, the side effects of aromatase inhibitors, mainly arthralgia, seriously affect the therapeutic efficacy of breast cancer or even terminate the treatment, which is also an important reason for poor drug compliance.[29] Based on the keywords clustering map and burst references, some randomized controlled trial (RCT) experiments have shown that acupuncture or electroacupuncture[30] can significantly improve aromatase inhibitor-associated arthralgia[27] and with long-term benefits.[31] These evidences strongly support its effectiveness. The gene discussed is CYP19A1; the disease is breast cancer.