ASPG and childhood leukemia: Chemotherapy drugs such as asparaginase were known to raise thrombosis risks.[13,14] In addition, CVC-associated embolism is a common complication of childhood leukemia, which accounts for nearly half of VTE events.[13–15] A retrospective study involving 652 children with acute lymphoblastic leukemia revealed that 57 children (8.7%) developed VTE, of which 74.1% occurred during induction chemotherapy, and only 5 cases occurred before asparaginase use.