KEGG enrichment findings based on current core genes indicated universally shared signaling pathways across EGFR tyrosine kinase inhibitor resistance, PD‐L1 expression and PD‐1 checkpoint pathway in cancer, C‐type lectin receptor signaling pathway, prolactin signaling pathway, chemical carcinogenesis‐receptor activation, toll‐like receptor signaling pathway, HIF‐1 signaling pathway. The gene discussed is CD274; the disease is cancer.