AKT1 and liver cancer: The objectives of this study are to investigate the anticancer effect of the combined action of PC and RES, specifically as follows: (1) investigate the growth inhibitory effects of PC and RES alone or together on colorectal and liver cancer cells, and (2) CACO‐2 cells as a representative model is used to reveal the possible mechanisms of their synergistic anticancer effects by studying the effects of PC and RES alone or in combination on cell clone formation, apoptosis, cell cycle, AKT, and other signaling pathways.