Importantly, however, Htt CAG expansion caused a specific splicing disruption in a common set of SE events in the in vivo and in vitro HD models (18.85% of the total striatal SE events, p-value: 0, Fisher’s exact test) (Fig 3A), which were mainly involved in ‘cell junction’ and ‘organization of synapse’ enriched GO terms (Fig 3B and S3 Table). This evidence concerns the gene HTT and Huntington disease.