ADAMTS6 and Huntington disease: Crem, a cAMP-responsive element modulator [31], Adamts6, ADAM metallopeptidase with thrombospondin type 1 motif, 6 [32] and Trpm4, TRP melastatin subgroup 4 protein—TRPM4 [33] were interesting targets, already implicated with HD and showing aberrant SE (SE increase in Htt CAG expanded alleles) in both Q111 and Q175 striata.