Crem, a cAMP-responsive element modulator [31], Adamts6, ADAM metallopeptidase with thrombospondin type 1 motif, 6 [32] and Trpm4, TRP melastatin subgroup 4 protein—TRPM4 [33] were interesting targets, already implicated with HD and showing aberrant SE (SE increase in Htt CAG expanded alleles) in both Q111 and Q175 striata. Here, HTT is linked to Huntington disease.