INS and metabolic syndrome: The explanation of these correlations were demonstrated by previous research [12], which revealed the binding of hsa-miR-221 to important genes and components of the insulin/insulin-like signaling pathway, as well as their relationship with metabolic syndrome, diabetes, and diabetic implications, Lustig et al. [40], who revealed that hsa-miR-221 could have a role in IR regulation via reducing adiponectin expression, and Meerson et al. [41] who showed that hsa-miR-221 expression in subcutaneous adipose tissue was positively linked with BMI in nondiabetic Pima Indians.