The combination of two molecules involved in refining CFTR protein folding (elexacaftor/tezacaftor) and another molecule to potentiate CFTR ion gating function (ivacaftor) has improved lung function, sweat chloride levels, and overall quality of life in people with cystic fibrosis (pwCF) (1, 2). Here, CFTR is linked to cystic fibrosis.