Regenerative thrombocytopenia was either achieved by diphtheria toxin (DT)-induced apoptosis of megakaryocytes in the bone marrow of transgenic megakaryocyte specific iDTR mice (PF4 iDTR) or by anti-GPIbα antibody (R300)-mediated depletion of platelets in the circulation (Figure 2A). This evidence concerns the gene PF4 and Thrombocytopenia.