VDAC1 and Spastic paraplegia: PTP models proposed earlier, such as heterooligomeric complexes of adenine nucleotide translocase, voltage-dependent anion channel (VDAC), peripheral benzodiazepine receptor, cyclophilin D (CyPD), creatine kinase, and Bax/Bcl-2 proteins [14,15,16]; or phosphate transporter and CyPD [17]; or VDAC, CyPD, and spastic paraplegia 7 [18], were rejected based on the data on the genetic ablation of putative PTP components [19,20,21,22,23,24,25,26].