CD40 and non-small cell lung carcinoma: Single-cell RNA sequencing (scRNA-seq) of human and murine NSCLC identified a new cluster of DCs—mature DCs enriched in immunoregulatory molecules (mregDCs) [26]—that express activation markers (CD40, CCR7, IL12β) and regulatory proteins (PD-L1, PD-L2, FAS), as well as proteins mediating a Th2 response (IL4Rɑ, IL4I1, CCL22).