MAPT and Alzheimer disease: The specific mechanisms responsible for the dying-back degeneration of neurons in AD are still not fully defined, but various hypotheses have been put forward, including deficits in FAT [4], signaling abnormalities elicited by Aβ and Tau [61,62], and Aβ and Tau aggregation, which has also been linked to FAT inhibition [9,23,36].